Gender Influences [Ca 2+ ] i During Metabolic Inhibition in Myocytes Overexpressing the Na + -Ca 2+ Exchanger
نویسندگان
چکیده
منابع مشابه
Gender influences [Ca(2+)](i) during metabolic inhibition in myocytes overexpressing the Na(+)-Ca(2+) exchanger.
BACKGROUND The Na(+)-Ca(2+) exchanger (NCX) may contribute to Ca(2+) overload and injury in ischemic cardiomyocytes. Recently, NCX overexpression was reported to increase ischemia/reperfusion injury in male and oophorectomized female but not in female mice. We therefore measured the effects of gender and estrogen on [Ca(2+)](i) and [Na(+)](i) during metabolic inhibition (MI) in myocytes from wi...
متن کاملGender Influences [Ca]i During Metabolic Inhibition in Myocytes Overexpressing the Na-Ca Exchanger
Background—The Na-Ca exchanger (NCX) may contribute to Ca overload and injury in ischemic cardiomyocytes. Recently, NCX overexpression was reported to increase ischemia/reperfusion injury in male and oophorectomized female but not in female mice. We therefore measured the effects of gender and estrogen on [Ca]i and [Na ]i during metabolic inhibition (MI) in myocytes from wild-type (WT) and tran...
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Postmyocardial infarction (MI) rat myocytes demonstrated depressed Na(+)/Ca(2+) exchange (NCX1) activity, altered contractility, and intracellular Ca(2+) concentration ([Ca(2+)](i)) transients. We investigated whether NCX1 downregulation in normal myocytes resulted in contractility changes observed in MI myocytes. Myocytes infected with adenovirus expressing antisense (AS) oligonucleotides to N...
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We measured [Ca]i and [Na ]i in isolated transgenic (TG) mouse myocytes overexpressing the Na -Ca exchanger and in wild-type (WT) myocytes. In TG myocytes, the peak systolic level and amplitude of electrically stimulated (ES) [Ca]i transients (0.25 Hz) were not significantly different from those in WT myocytes, but the time to peak [Ca]i was significantly prolonged. The decline of ES [Ca]i tran...
متن کاملEffects of Na /Ca exchanger downregulation on contractility and [Ca ]i transients in adult rat myocytes
GEORGE M. TADROS,2* XUE-QIAN ZHANG,1* JIANLIANG SONG,1 LOIS L. CARL,1 LAWRENCE I. ROTHBLUM,1 QIANG TIAN,1 JEREMY DUNN,3 JONATHAN LYTTON,3 AND JOSEPH Y. CHEUNG1,2 1Weis Center for Research and 2Department of Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822; and 3Department of Biochemistry and Molecular Biology, University of Calgary Health Sciences Center, Calgary, Alberta, Canad...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/hc4001.097038